Alzheimer's biomarkers in daily practice (ABIDE) project: Rationale and design.

ABSTRACT:

Introduction

The Alzheimer's biomarkers in daily practice (ABIDE) project is designed to translate knowledge on diagnostic tests (magnetic resonance imaging [MRI], cerebrospinal fluid [CSF], and amyloid positron emission tomography [PET]) to daily clinical practice with a focus on mild cognitive impairment (MCI).

Methods

ABIDE is a 3-year project with a multifaceted design and is structured into interconnected substudies using both quantitative and qualitative research methods.

Results

Based on retrospective data, we develop personalized risk estimates for MCI patients. Prospectively, we collect MRI and CSF data from 200 patients from local memory clinics and amyloid PET from 500 patients in a tertiary setting, to optimize application of these tests in daily practice.

SUBMITTER: de Wilde A 

PROVIDER: S-EPMC5318541 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature