Human enterovirus 71 protein interaction network prompts antiviral drug repositioning.

ABSTRACT: As a predominant cause of human hand, foot, and mouth disease, enterovirus 71 (EV71) infection may lead to serious diseases and result in severe consequences that threaten public health and cause widespread panic. Although the systematic identification of physical interactions between viral proteins and host proteins provides initial information for the recognition of the cellular mechanism involved in viral infection and the development of new therapies, EV71-host protein interactions have not been explored. Here, we identified interactions between EV71 proteins and host cellular proteins and confirmed the functional relationships of EV71-interacting proteins (EIPs) with virus proliferation and infection by integrating a human protein interaction network and by functional annotation. We f

SUBMITTER: Han L 

PROVIDER: S-EPMC5318855 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature