Distinct signatures of dental plaque metabolic byproducts dictated by periodontal inflammatory status.

ABSTRACT: Onset of chronic periodontitis is associated with an aberrant polymicrobial community, termed dysbiosis. Findings regarding its etiology obtained using high-throughput sequencing technique suggested that dysbiosis holds a conserved metabolic signature as an emergent property. The purpose of this study was to identify robust biomarkers for periodontal inflammation severity. Furthermore, we investigated disease-associated metabolic signatures of periodontal microbiota using a salivary metabolomics approach. Whole saliva samples were obtained from adult subjects before and after removal of supragingival plaque (debridement). Periodontal inflamed surface area (PISA) was employed as an indicator of periodontal inflammatory status. Based on multivariate analyses using pre-debridement salivary me

SUBMITTER: Sakanaka A 

PROVIDER: S-EPMC5318866 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature