Cbx3/HP1γ deficiency confers enhanced tumor-killing capacity on CD8⁺ T cells.

ABSTRACT: Cbx3/HP1γ is a histone reader whose function in the immune system is not completely understood. Here, we demonstrate that in CD8⁺ T cells, Cbx3/HP1γ insufficiency leads to chromatin remodeling accompanied by enhanced Prf1, Gzmb and Ifng expression. In tumors obtained from Cbx3/HP1γ-insufficient mice or wild type mice treated with Cbx3/HP1γ-insufficient CD8⁺ T cells, there is an increase of CD8⁺ effector T cells expressing the stimulatory receptor Klrk1/NKG2D, a decrease in CD4⁺ CD25⁺ FOXP3⁺ regulatory T cells (Treg cells) as well as CD25⁺ CD4⁺ T cells expressing the inhibitory receptor CTLA4. Together these changes in the tumor immune environment may have mitigated tumor burden in Cbx3/HP1γ-insufficient

SUBMITTER: Sun M 

PROVIDER: S-EPMC5318867 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature