Impact of disease stage and aetiology on survival in hepatocellular carcinoma: implications for surveillance.

ABSTRACT:

Background

Variation in survival in hepatocellular carcinoma (HCC) has been attributed to different aetiologies or disease stages at presentation. While international guidelines recommend surveillance of high-risk groups to permit early diagnosis and curative treatment, the evidence that surveillance decreases disease-specific mortality is weak.

Methods

We compared HCC survival figures from Japan (n=1174) and Hong Kong (n=1675) over similar time periods (Japan 2000-2013, Hong Kong, China 2003-2014). The former has an intensive national surveillance programme, while the latter has none. We also analysed changes in survival in Japan over a 50-year period including data from before and after institution of a national HCC surveillance programme.

Results

In Japan, over 75%

SUBMITTER: Johnson P 

PROVIDER: S-EPMC5318967 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature