Interaction between HCMV pUL83 and human AIM2 disrupts the activation of the AIM2 inflammasome.

ABSTRACT:

Background

AIM2, a cytosolic DNA sensor, plays an important role during infection caused by pathogens with double-stranded DNA; however, its role in human cytomegalovirus (HCMV) infection remains unclear. Previously, we showed an increase in AIM2 protein levels during the early stage of HCMV infection and a decrease 24 h post infection. Because HCMV has developed a variety of strategies to evade host immunity, we speculated that this decline might be attributed to a viral immune escape mechanism. The tegument protein pUL83 is an important immune evasion protein and several studies have reported that pUL83 binds to specific cellular proteins, such as AIM2-like receptor IFI16, to affect their functions. To determine whether pUL83 contributes to the variation in AIM2 levels during HCM

SUBMITTER: Huang Y 

PROVIDER: S-EPMC5319029 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature