A functional SNP associated with atopic dermatitis controls cell type-specific methylation of the VSTM1 gene locus.

ABSTRACT:

Background

Expression quantitative trait loci (eQTL) databases represent a valuable resource to link disease-associated SNPs to specific candidate genes whose gene expression is significantly modulated by the SNP under investigation. We previously identified signal inhibitory receptor on leukocytes-1 (SIRL-1) as a powerful regulator of human innate immune cell function. While it is constitutively high expressed on neutrophils, on monocytes the SIRL-1 surface expression varies strongly between individuals. The underlying mechanism of regulation, its genetic control as well as potential clinical implications had not been explored yet.

Methods

Whole blood eQTL data of a Chinese cohort was used to identify SNPs regulating the expression of VSTM1, the gene encoding SIRL-1. The ge

SUBMITTER: Kumar D 

PROVIDER: S-EPMC5319034 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature