Identification of miRNA-mRNA crosstalk in CD4⁺ T cells during HIV-1 infection by integrating transcriptome analyses.

ABSTRACT:

Background

HIV-1-infected long-term nonprogressors (LTNPs) are characterized by infection with HIV-1 more than 7-10 years, but keeping high CD4⁺ T cell counts and low viral load in the absence of antiretroviral treatment, while loss of CD4⁺ T cells and high viral load were observed in the most of HIV-1-infected individuals with chronic progressors (CPs) However, the mechanisms of different clinical outcomes in HIV-1 infection needs to be further resolved.

Methods

To identify microRNAs (miRNAs) and their target genes related to distinct clinical outcomes in HIV-1 infection, we performed the integrative transcriptome analyses in two series GSE24022 and GSE6740 by GEO2R, R, TargetScan, miRDB, and Cytoscape softwares. The functional pathways of these differ

SUBMITTER: Liao Q 

PROVIDER: S-EPMC5319073 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature