Altered anterior-posterior connectivity through the arcuate fasciculus in temporal lobe epilepsy.

ABSTRACT: How the interactions between cortices through a specific white matter pathway change during cognitive processing in patients with epilepsy remains unclear. Here, we used surface-based structural connectivity analysis to examine the change in structural connectivity with Broca's area/the right Broca's homologue in the lateral temporal and inferior parietal cortices through the arcuate fasciculus (AF) in 17 patients with left temporal lobe epilepsy (TLE) compared with 17 healthy controls. Then, we investigated its functional relevance to the changes in task-related responses and task-modulated functional connectivity with Broca's area/the right Broca's homologue during a semantic classification task of a single word. The structural connectivity through the AF pathway and task-modulated funct

SUBMITTER: Takaya S 

PROVIDER: S-EPMC5319387 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature