Quantitative assessment of the relationship between RASSF1A gene promoter methylation and bladder cancer (PRISMA).

ABSTRACT:

Background

Methylation of the Ras-association domain family 1 isoform A (RASSF1A) gene promoter region is thought to participate in the initiation and development of many different cancers. However, in bladder cancer the role of RASSF1A methylation was unclear. To evaluate the relationship between RASSF1A methylation and bladder cancer, a quantitative assessment of an independent meta-analysis was performed. In addition, a DNA methylation microarray database from the cancer genome atlas (TCGA) project was used to validate the results of the meta-analysis.

Methods

We searched published articles from computerized databases, and DNA methylation data were extracted from TCGA project. All data were analyzed by R software.

Results

The results of the meta-analysis indicated

SUBMITTER: Zhan L 

PROVIDER: S-EPMC5319510 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature