Shortened Antimicrobial Treatment for Acute Otitis Media in Young Children.

ABSTRACT:

Background

Limiting the duration of antimicrobial treatment constitutes a potential strategy to reduce the risk of antimicrobial resistance among children with acute otitis media.

Methods

We assigned 520 children, 6 to 23 months of age, with acute otitis media to receive amoxicillin-clavulanate either for a standard duration of 10 days or for a reduced duration of 5 days followed by placebo for 5 days. We measured rates of clinical response (in a systematic fashion, on the basis of signs and symptomatic response), recurrence, and nasopharyngeal colonization, and we analyzed episode outcomes using a noninferiority approach. Symptom scores ranged from 0 to 14, with higher numbers indicating more severe symptoms.

Results

Children who were treated with amoxicillin-clavula

SUBMITTER: Hoberman A 

PROVIDER: S-EPMC5319589 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature