Association of Traumatic Brain Injury With Late-Life Neurodegenerative Conditions and Neuropathologic Findings.

ABSTRACT:

Importance

The late effects of traumatic brain injury (TBI) are of great interest, but studies characterizing these effects are limited.

Objective

To determine whether TBI with loss of consciousness (LOC) is associated with an increased risk for clinical and neuropathologic findings of Alzheimer disease (AD), Parkinson disease (PD), and other dementias.

Design, setting, and participants

This study analyzed data from the Religious Orders Study (ROS), Memory and Aging Project (MAP), and Adult Changes in Thought study (ACT). All ROS and MAP participants and a subset of ACT participants consent to autopsy. Studies performed annual (ROS and MAP) or biennial (ACT) cognitive and clinical testing to identify incident cases of dementia and AD. The 7130 participants included me

SUBMITTER: Crane PK 

PROVIDER: S-EPMC5319642 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature