Interferon-γ Limits Diabetogenic CD8⁺ T-Cell Effector Responses in Type 1 Diabetes.

ABSTRACT: Type 1 diabetes development in the NOD mouse model is widely reported to be dependent on high-level production by autoreactive CD4⁺ and CD8⁺ T cells of interferon-γ (IFN-γ), generally considered a proinflammatory cytokine. However, IFN-γ can also participate in tolerance-induction pathways, indicating it is not solely proinflammatory. This study addresses how IFN-γ can suppress activation of diabetogenic CD8⁺ T cells. CD8⁺ T cells transgenically expressing the diabetogenic AI4 T-cell receptor adoptively transferred disease to otherwise unmanipulated NOD.IFN-γ^null , but not standard NOD, mice. AI4 T cells only underwent vigorous intrasplenic proliferation in NOD.IFN-γ^null recipients. Disease-protective IFN-γ cou

SUBMITTER: Driver JP 

PROVIDER: S-EPMC5319715 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature