Placental genetic variations in vitamin D metabolism and birthweight.

ABSTRACT:

Introduction

Vitamin D has pleiotropic functions that regulate fetal growth and development. We investigated associations of common placental genetic variations in vitamin D metabolism with birthweight.

Methods

The study was conducted among participants (506 maternal-infant pairs) of a pregnancy cohort study. Data were collected using interviewer-administered questionnaires and post-delivery medical record abstraction. DNA, extracted from placental samples collected at delivery, was genotyped for eight single nucleotide polymorphisms (SNPs) in five vitamin D metabolism genes (CUBN, LRP2, VDR, GC, and CYP2R1). Linear and logistic regression models were used to evaluate associations of SNPs with birthweight and risk of low birthweight, respectively. Effect modification of asso

SUBMITTER: Workalemahu T 

PROVIDER: S-EPMC5319727 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature