Predictors of durable immune responses six months after the last vaccination in preventive HIV vaccine trials.

ABSTRACT:

Background

The evaluation of durable immune responses is important in HIV vaccine research and development. The efficiency of such evaluation could be increased by incorporating predictors of the responses in the statistical analysis. In this paper, we investigated whether and how baseline demographic variables and immune responses measured two weeks after vaccination predicted durable immune responses measured six months later.

Methods

We included data from seven preventive HIV vaccine regimens evaluated in three clinical trials: a Phase 1 study of four DNA, NYVAC and/or AIDSVAX vaccine regimens (HVTN096), a Phase 2 study of two DNA and/or MVA vaccine regimens (HVTN205), and a Phase 3 study of a single ALVAC/AIDSVAX regimen (RV144). Regularized random forests and linear reg

SUBMITTER: Huang Y 

PROVIDER: S-EPMC5319823 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature