Transcriptional Networks Controlled by NKX2-1 in the Development of Forebrain GABAergic Neurons.

ABSTRACT: The embryonic basal ganglia generates multiple projection neurons and interneuron subtypes from distinct progenitor domains. Combinatorial interactions of transcription factors and chromatin are thought to regulate gene expression. In the medial ganglionic eminence, the NKX2-1 transcription factor controls regional identity and, with LHX6, is necessary to specify pallidal projection neurons and forebrain interneurons. Here, we dissected the molecular functions of NKX2-1 by defining its chromosomal binding, regulation of gene expression, and epigenetic state. NKX2-1 binding at distal regulatory elements led to a repressed epigenetic state and transcriptional repression in the ventricular zone. Conversely, NKX2-1 is required to establish a permissive chromatin state and transcriptional activ

SUBMITTER: Sandberg M 

PROVIDER: S-EPMC5319854 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature