The Genetic Architecture of Major Depressive Disorder in Han Chinese Women.

ABSTRACT:

Importance

Despite the moderate, well-demonstrated heritability of major depressive disorder (MDD), there has been limited success in identifying replicable genetic risk loci, suggesting a complex genetic architecture. Research is needed to quantify the relative contribution of classes of genetic variation across the genome to inform future genetic studies of MDD.

Objectives

To apply aggregate genetic risk methods to clarify the genetic architecture of MDD by estimating and partitioning heritability by chromosome, minor allele frequency, and functional annotations and to test for enrichment of rare deleterious variants.

Design, setting, and participants

The CONVERGE (China, Oxford, and Virginia Commonwealth University Experimental Research on Genetic Epidemiology) stu

SUBMITTER: Peterson RE 

PROVIDER: S-EPMC5319866 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature