Notch3 expression correlates with thyroid cancer differentiation, induces apoptosis, and predicts disease prognosis.

ABSTRACT:

Background

Thyroid tumorigenesis is characterized by a progressive loss of differentiation exhibited by a range of disease variants. The Notch receptor family (1-4) regulates developmental progression in both normal and cancerous tissues. This study sought to characterize the third Notch isoform (Notch3) across the various differentiated states of thyroid cancer, and determine its clinical impact.

Methods

Notch3 expression was analyzed in a tissue microarray of normal and pathologic thyroid biopsies from 155 patients. The functional role of Notch3 was then investigated by upregulating its expression in a follicular thyroid cancer (FTC) cell line.

Results

Notch3 expression regressed across decreasingly differentiated, increasingly malignant thyroid specimens, correlate

SUBMITTER: Somnay YR 

PROVIDER: S-EPMC5319883 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature