Natural History of the Central Structural Abnormalities in Choroideremia: A Prospective Cross-Sectional Study.

ABSTRACT:

Purpose

To describe in detail the central retinal structure of a large group of patients with choroideremia (CHM).

Design

A prospective, cross-sectional, descriptive study.

Participants

Patients (n = 97, age 6-71 years) with CHM and subjects with normal vision (n = 44; ages 10-50 years) were included.

Methods

Subjects were examined with spectral-domain optical coherence tomography (SD OCT) and near-infrared reflectance imaging. Visual acuity (VA) was measured during their encounter or obtained from recent ophthalmic examinations. Visual thresholds were measured in a subset of patients (n = 24) with automated static perimetry within the central regions (±15°) examined with SD OCT.

Main outcome measures

Visual acuity and visual thresholds; total nuclear la

SUBMITTER: Aleman TS 

PROVIDER: S-EPMC5319901 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature