Genetic polymorphisms in genes related to risk-taking behaviours predicting body mass index trajectory among Mexican American adolescents.

ABSTRACT:

Objectives

Obesity is associated with multiple health problems and often originates in childhood. The purpose is to investigate the associations of genetic polymorphisms in genes related to risk-taking behaviours with body mass index (BMI) trajectory over adolescence among Mexican Americans.

Methods

This study included 1229 Mexican American adolescents who participated in a large population-based cohort study in Houston, Texas. BMI data were obtained at baseline and two follow-ups. The median follow-up time was 59 months. Participants were genotyped for 672 functional and tagging variants in genes involved in the dopamine, serotonin and cannabinoid pathways.

Results

After adjusting for multiple comparisons, three genetic variants, namely, rs933271 and rs4646310 in COM

SUBMITTER: Zhao H 

PROVIDER: S-EPMC5319917 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature