Tract-specific white matter hyperintensities disrupt neural network function in Alzheimer's disease.

ABSTRACT:

Introduction

White matter hyperintensities (WMHs) increase the risk of Alzheimer's disease (AD). Whether WMHs are associated with the decline of functional neural networks in AD is debated.

Method

Resting-state functional magnetic resonance imaging and WMH were assessed in 78 subjects with increased amyloid levels on AV-45 positron emission tomography (PET) in different clinical stages of AD. We tested the association between WMH volume in major atlas-based fiber tract regions of interest (ROIs) and changes in functional connectivity (FC) between the tracts' projection areas within the default mode network (DMN).

Results

WMH volume within the inferior fronto-occipital fasciculus (IFOF) was the highest among all tract ROIs and associated with reduced FC in IFOF-connect

SUBMITTER: Taylor ANW 

PROVIDER: S-EPMC5319922 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature