Ontology highlight
ABSTRACT:
SUBMITTER: Qiu Z
PROVIDER: S-EPMC5320478 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Scientific reports 20170222
Gross chromosomal rearrangements (GCRs), including translocations, inversions amplifications, and deletions, can be causal events leading to malignant transformation. GCRs are thought to be triggered by DNA double strand breaks (DSBs), which in turn can be spontaneous or induced by external agents (eg. cytotoxic chemotherapy, ionizing radiation). It has been shown that induction of DNA DSBs at two defined loci can produce stable balanced chromosomal translocations, however, a single engineered D ...[more]