Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases.

ABSTRACT: We recently reported that differential gene expression and DNA methylation profiles in blood leukocytes of apparently healthy smokers predicts with remarkable efficiency diseases and conditions known to be causally associated with smoking, suggesting that blood-based omic profiling of human populations may be useful for linking environmental exposures to potential health effects. Here we report on the sex-specific effects of tobacco smoking on transcriptomic and epigenetic features derived from genome-wide profiling in white blood cells, identifying 26 expression probes and 92 CpG sites, almost all of which are affected only in female smokers. Strikingly, these features relate to numerous genes with a key role in the pathogenesis of cardiovascular disease, especially thrombin signaling, in

SUBMITTER: Chatziioannou A 

PROVIDER: S-EPMC5320491 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature