Detecting Gene-Gene Interactions Associated with Multiple Complex Traits with U-Statistics.

ABSTRACT: Many complex diseases, such as psychiatric and behavioral disorders, are commonly characterized through various measurements that reflect physical, behavioral and psychological aspects of diseases. While it remains a great challenge to find a unified measurement to characterize a disease, the available multiple phenotypes can be analyzed jointly in the genetic association study. Simultaneously testing these phenotypes has many advantages, including considering different aspects of the disease in the analysis, and utilizing correlated phenotypes to improve the power of detecting disease-associated variants. Furthermore, complex diseases are likely caused by the interplay of multiple genetic variants through complicated mechanisms. Considering gene-gene interactions in the joint association

SUBMITTER: Li M 

PROVIDER: S-EPMC5320542 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature