A Comprehensive Metabolomic Investigation in Urine of Mice Exposed to Strontium-90.

ABSTRACT: Internal emitters such as Strontium-90 ((90)Sr) pose a substantial health risk during and immediately after a nuclear disaster or detonation of an improvised device. The environmental persistency and potency of (90)Sr calls for urgent development of high-throughput tests to establish levels of exposure and to help triage potentially exposed individuals who were in the immediate area of the disaster. In response to these concerns, our team focused on developing a robust metabolomic profile for (90)Sr exposure in urine using a mouse model. The sensitivity of modern time-of-flight mass spectrometry (TOFMS) combined with the separation power of ultra performance liquid chromatography (UPLC) was used to determine perturbations in the urinary metabolome of mice exposed to (90)Sr. The recently de

SUBMITTER: Goudarzi M 

PROVIDER: S-EPMC5320572 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature