Pan-genomic perspective on the evolution of the Staphylococcus aureus USA300 epidemic.

ABSTRACT: Staphylococcus aureus USA300 represents the dominant community-associated methicillin-resistant S. aureus lineage in the USA, where it is a major cause of skin and soft tissue infections. Previous comparative genomic studies have described the population structure and evolution of USA300 based on geographically restricted isolate collections. Here, we investigated the USA300 population by sequencing genomes of a geographically distributed panel of 191 clinical S. aureus isolates belonging to clonal complex 8 (CC8), derived from the Tigecycline Evaluation and Surveillance Trial program. Isolates were collected at 12 healthcare centres across nine USA states in 2004, 2009 or 2010. Reconstruction of evolutionary relationships revealed that CC8 was dominated by USA300 isol

SUBMITTER: Jamrozy DM 

PROVIDER: S-EPMC5320670 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature