Design principles for robust vesiculation in clathrin-mediated endocytosis.

ABSTRACT: A critical step in cellular-trafficking pathways is the budding of membranes by protein coats, which recent experiments have demonstrated can be inhibited by elevated membrane tension. The robustness of processes like clathrin-mediated endocytosis (CME) across a diverse range of organisms and mechanical environments suggests that the protein machinery in this process has evolved to take advantage of some set of physical design principles to ensure robust vesiculation against opposing forces like membrane tension. Using a theoretical model for membrane mechanics and membrane protein interaction, we have systematically investigated the influence of membrane rigidity, curvature induced by the protein coat, area covered by the protein coat, membrane tension, and force from actin polymerization

SUBMITTER: Hassinger JE 

PROVIDER: S-EPMC5320970 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature