EBI3 regulates the NK cell response to mouse cytomegalovirus infection.

ABSTRACT: Natural killer (NK) cells are key mediators in the control of cytomegalovirus infection. Here, we show that Epstein-Barr virus-induced 3 (EBI3) is expressed by human NK cells after NKG2D or IL-12 plus IL-18 stimulation and by mouse NK cells during mouse cytomegalovirus (MCMV) infection. The induction of EBI3 protein expression in mouse NK cells is a late activation event. Thus, early activation events of NK cells, such as IFNγ production and CD69 expression, were not affected in EBI3-deficient (Ebi3^-/- ) C57BL/6 (B6) mice during MCMV infection. Furthermore, comparable levels of early viral replication in spleen and liver were observed in MCMV-infected Ebi3^-/- and wild-type (WT) B6 mice. Interestingly, the viral load in salivary glands and o

SUBMITTER: Jensen H 

PROVIDER: S-EPMC5321027 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature