Reactive oxygen species induce virus-independent MAVS oligomerization in systemic lupus erythematosus.

ABSTRACT: The increased expression of genes induced by type I interferon (IFN) is characteristic of viral infections and systemic lupus erythematosus (SLE). We showed that mitochondrial antiviral signaling (MAVS) protein, which normally forms a complex with retinoic acid gene I (RIG-I)-like helicases during viral infection, was activated by oxidative stress independently of RIG-I helicases. We found that chemically generated oxidative stress stimulated the formation of MAVS oligomers, which led to mitochondrial hyperpolarization and decreased adenosine triphosphate production and spare respiratory capacity, responses that were not observed in similarly treated cells lacking MAVS. Peripheral blood lymphocytes of SLE patients also showed spontaneous MAVS oligomerization that correlated with the increa

SUBMITTER: Buskiewicz IA 

PROVIDER: S-EPMC5321043 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature