Altered brain network modules induce helplessness in major depressive disorder.

ABSTRACT:

Objective

The abnormal brain functional connectivity (FC) has been assumed to be a pathophysiological aspect of major depressive disorder (MDD). However, it is poorly understood, regarding the underlying patterns of global FC network and their relationships with the clinical characteristics of MDD.

Methods

Resting-state functional magnetic resonance imaging data were acquired from 16 first episode, medication-naïve MDD patients and 16 healthy control subjects. The global FC network was constructed using 90 brain regions. The global topological patterns, e.g., small-worldness and modularity, and their relationships with depressive characteristics were investigated. Furthermore, the participant coefficient and module degree of MDD patients were measured to reflect the regional

SUBMITTER: Peng D 

PROVIDER: S-EPMC5321069 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature