Validation of a Prediction Tool for Chemotherapy Toxicity in Older Adults With Cancer.

ABSTRACT:

Purpose

Older adults are at increased risk for chemotherapy toxicity, and standard oncology assessment measures cannot identify those at risk. A predictive model for chemotherapy toxicity was developed (N = 500) that consisted of geriatric assessment questions and other clinical variables. This study aims to externally validate this model in an independent cohort (N = 250).

Patients and methods

Patients age ≥ 65 years with a solid tumor, fluent in English, and who were scheduled to receive a new chemotherapy regimen were recruited from eight institutions. Risk of chemotherapy toxicity was calculated (low, medium, or high risk) on the basis of the prediction model before the start of chemotherapy. Chemotherapy-related toxicity was captured (grade 3 [hospitalization indicated]

SUBMITTER: Hurria A 

PROVIDER: S-EPMC5321104 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature