Paradoxical effects of SAA on lipoprotein oxidation suggest a new antioxidant function for SAA.

ABSTRACT: Oxidative stress and inflammation, which involve a dramatic increase in serum amyloid A (SAA) levels, are critical in the development of atherosclerosis. Most SAA circulates on plasma HDL particles, altering their cardioprotective properties. SAA-enriched HDL has diminished anti-oxidant effects on LDL, which may contribute to atherogenesis. We determined combined effects of SAA enrichment and oxidation on biochemical changes in HDL. Normal human HDLs were incubated with SAA, oxidized by various factors (Cu²⁺, myeloperoxidase, H₂O₂, OCl^-), and analyzed for lipid and protein modifications and biophysical remodeling. Three novel findings are reported: addition of SAA reduces oxidation of HDL and LDL lipids; oxidation of SAA-containing HDL in the pre

SUBMITTER: Jayaraman S 

PROVIDER: S-EPMC5321215 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature