The risk of disabling, surgery and reoperation in Crohn's disease - A decision tree-based approach to prognosis.

ABSTRACT:

Introduction

Crohn's disease (CD) is a chronic inflammatory bowel disease known to carry a high risk of disabling and many times requiring surgical interventions. This article describes a decision-tree based approach that defines the CD patients' risk or undergoing disabling events, surgical interventions and reoperations, based on clinical and demographic variables.

Materials and methods

This multicentric study involved 1547 CD patients retrospectively enrolled and divided into two cohorts: a derivation one (80%) and a validation one (20%). Decision trees were built upon applying the CHAIRT algorithm for the selection of variables.

Results

Three-level decision trees were built for the risk of disabling and reoperation, whereas the risk of surgery was described in a t

SUBMITTER: Dias CC 

PROVIDER: S-EPMC5321294 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature