The renal consequences of maternal obesity in offspring are overwhelmed by postnatal high fat diet.

ABSTRACT:

Aims/hypothesis

Developmental programming induced by maternal obesity influences the development of chronic disease in offspring. In the present study, we aimed to determine whether maternal obesity exaggerates obesity-related kidney disease.

Methods

Female C57BL/6 mice were fed high-fat diet (HFD) for six weeks prior to mating, during gestation and lactation. Male offspring were weaned to normal chow or HFD. At postnatal Week 8, HFD-fed offspring were administered one dose streptozotocin (STZ, 100 mg/kg i.p.) or vehicle control. Metabolic parameters and renal functional and structural changes were observed at postnatal Week 32.

Results

HFD-fed offspring had increased adiposity, glucose intolerance and hyperlipidaemia, associated with increased albuminuria and serum c

SUBMITTER: Glastras SJ 

PROVIDER: S-EPMC5321436 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature