Analysis of immune cell populations in atrial myocardium of patients with atrial fibrillation or sinus rhythm.

ABSTRACT:

Background

Atrial fibrillation (AF) is the most common arrhythmia and despite obvious clinical importance remains its pathogenesis only partially explained. A relation between inflammation and AF has been suggested by findings of increased inflammatory markers in AF patients.

Objective

The goal of this study was to characterize morphologically and functionally CD45-positive inflammatory cell populations in atrial myocardium of patients with AF as compared to sinus rhythm (SR).

Methods

We examined 46 subjects (19 with AF, and 27 in SR) undergoing coronary bypass or valve surgery. Peroperative bioptic samples of the left and the right atrial tissue were examined using immunohistochemistry.

Results

The number of CD3+ T-lymphocytes and CD68-KP1+ cells were elevated

SUBMITTER: Smorodinova N 

PROVIDER: S-EPMC5321459 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature