Intact Ventral Striatal Prediction Error Signaling in Medicated Schizophrenia Patients.

ABSTRACT:

Background

Midbrain dopaminergic neurons code a computational quantity, reward prediction error (RPE), which has been causally related to learning. Recently, this insight has been leveraged to link phenomenological and biological levels of understanding in psychiatric disorders, such as schizophrenia. However, results have been mixed, possibly due to small sample sizes. Here we present results from two studies with relatively large Ns to assess VS RPE in schizophrenia.

Methods

In the current study we analyzed data from two independent studies, involving a total of 87 chronic medicated schizophrenia patients and 61 controls. Subjects completed a probabilistic reinforcement-learning task in conjunction with fMRI scanning. We fit each participant's choice behavior to a Q-learni

SUBMITTER: Culbreth AJ 

PROVIDER: S-EPMC5321567 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature