Comparison of oscillatory activity in subthalamic nucleus in Parkinson's disease and dystonia.

ABSTRACT:

Objectives

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has been successfully used to treat both Parkinson's disease (PD) and dystonia. Local field potentials (LFPs) recorded from the STN of PD patients demonstrate prominent beta frequency band activity. It is unclear whether such activity occurs in the STN in dystonia, and, if not, whether dystonia has another distinctive neural population activity in the STN.

Methods

Twelve patients with PD, and eight patients with dystonia underwent DBS electrode implantation targeting the STN. Seven dystonia patients were off medication and one was on aripiprazole and clonazepam. LFPs were recorded from the DBS electrodes in PD in the on/off medication states and in dystonia. Power spectra and temporal dynamics measured

SUBMITTER: Geng X 

PROVIDER: S-EPMC5321603 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature