Non-covalent interactions in controlling pH-responsive behaviors of self-assembled nanosystems.

ABSTRACT: Self-assembly and associated dynamic and reversible non-covalent interactions are the basis of protein biochemistry (e.g., protein folding) and development of sophisticated nanomaterial systems that can respond to and amplify biological signals. In this study, we report a systematic investigation of non-covalent interactions that affect the pH responsive behaviors and resulting supramolecular self-assembly of a series of ultra-pH sensitive (UPS) block copolymers. Increase of hydrophobic and π-π stacking interactions led to the decrease of pKa values. In contrast, enhancement of direct ionic binding between cationic ammonium groups and anionic counter ions gave rise to increased pKa. Moreover, hydration of hydrophobic surfaces and hydrogen bonding interactions may also play a role in the se

SUBMITTER: Li Y 

PROVIDER: S-EPMC5321650 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature