Regulation and function of MeCP2 Ser421 phosphorylation in U50488-induced conditioned place aversion in mice.

ABSTRACT:

Rationale

Phosphorylation of the methyl DNA-binding protein MeCP2 at Ser421 (pMeCP2-S421) is induced in corticolimbic brain regions during exposure to drugs of abuse and modulates reward-driven behaviors. However, whether pMeCP2-S421 is also involved in behavioral adaptations to aversive drugs is unknown.

Objectives

Our goal was to establish the role and regulation of pMeCP2-S421 in corticolimbic brain regions of mice upon acute treatment with the kappa opioid receptor agonist U50488 and during the expression of U50488-induced conditioned place aversion (CPA).

Methods

pMeCP2-S421 levels were measured in the nucleus accumbens (NAc), prelimbic cortex, infralimbic cortex (ILC), and basolateral amygdala (BLA) of male mice after intraperitoneal administration of U50488 and

SUBMITTER: Zannas AS 

PROVIDER: S-EPMC5321784 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature