Multiparametric imaging of brain hemodynamics and function using gas-inhalation MRI.

ABSTRACT: Diagnosis and treatment monitoring of cerebrovascular diseases routinely require hemodynamic imaging of the brain. Current methods either only provide part of the desired information or require the injection of multiple exogenous agents. In this study, we developed a multiparametric imaging scheme for the imaging of brain hemodynamics and function using gas-inhalation MRI. The proposed technique uses a single MRI scan to provide simultaneous measurements of baseline venous cerebral blood volume (vCBV), cerebrovascular reactivity (CVR), bolus arrival time (BAT), and resting-state functional connectivity (fcMRI). This was achieved with a novel, concomitant O₂ and CO₂ gas inhalation paradigm, rapid MRI image acquisition with a 9.3min BOLD sequence, and an advanced algori

SUBMITTER: Liu P 

PROVIDER: S-EPMC5322044 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature