Tumour cell conditioned medium reveals greater M2 skewing of macrophages in the absence of properdin.

ABSTRACT:

Introduction

The tumour microenvironment is shaped by the interaction of immune, non immune, and tumour cells present in close proximity. Tumour cells direct the development of a locally immune suppressed state, affecting the activity of anti tumour T cells and preparing the escape phase of tumour development. Macrophages in the tumour typically develop into so-called tumour associated macrophages with a distinct profile of activities which lead to a reduction in inflammation and antigen presentation. The direct impact of tumour cell conditioned medium on the activity profile of macrophages in dependence of their complement component expression has not yet been investigated.

Methods

In our in vitro study, macrophages differentiated from bone marrows of properdin deficient an

SUBMITTER: Al-Rayahi IA 

PROVIDER: S-EPMC5322164 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature