Specific and Novel microRNAs Are Regulated as Response to Fungal Infection in Human Dendritic Cells.

ABSTRACT: Within the last two decades, the incidence of invasive fungal infections has been significantly increased. They are characterized by high mortality rates and are often caused by Candida albicans and Aspergillus fumigatus. The increasing number of infections underlines the necessity for additional anti-fungal therapies, which require extended knowledge of gene regulations during fungal infection. MicroRNAs are regulators of important cellular processes, including the immune response. By analyzing their regulation and impact on target genes, novel therapeutic and diagnostic approaches may be developed. Here, we examine the role of microRNAs in human dendritic cells during fungal infection. Dendritic cells represent the bridge between the innate and the adaptive immune systems.

SUBMITTER: Dix A 

PROVIDER: S-EPMC5322194 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature