The infralimbic and prelimbic cortices contribute to the inhibitory control of cocaine-seeking behavior during a discriminative stimulus task in rats.

ABSTRACT: The infralimbic and prelimbic (IL and PL, respectively) regions of the medial prefrontal cortex regulate the control of drug-seeking behavior. However, their roles in cocaine seeking in a discriminative stimulus (DS)-based self-administration task are unclear. To address this issue, male Sprague Dawley rats were trained on a DS task in which, on a trial-by-trial basis, a DS+ indicated that a lever press would produce a cocaine infusion, whereas a distinct DS- indicated that a lever press would produce nothing. IL and PL inactivation via GABA receptor activation decreased performance accuracy and disinhibited behavioral responding on DS- trials, resulting in greater lever pressing during the DS- presentation. This was accompanied by a decrease in cocaine infusions obtained, a finding confir

SUBMITTER: Gutman AL 

PROVIDER: S-EPMC5322251 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature