β₂-adrenergic receptor control of endosomal PTH receptor signaling via Gβγ.

ABSTRACT: Cells express several G-protein-coupled receptors (GPCRs) at their surfaces, transmitting simultaneous extracellular hormonal and chemical signals into cells. A comprehensive understanding of mechanisms underlying the integrated signaling response induced by distinct GPCRs is thus required. Here we found that the β₂-adrenergic receptor, which induces a short cAMP response, prolongs nuclear cAMP and protein kinase A (PKA) activation by promoting endosomal cAMP production in parathyroid hormone (PTH) receptor signaling through the stimulatory action of G protein Gβγ subunits on adenylate cyclase type 2.

SUBMITTER: Jean-Alphonse FG 

PROVIDER: S-EPMC5322277 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature