An experimental study on the impacts of inspiratory and expiratory muscles activities during mechanical ventilation in ARDS animal model.

ABSTRACT: In spite of intensive investigations, the role of spontaneous breathing (SB) activity in ARDS has not been well defined yet and little has been known about the different contribution of inspiratory or expiratory muscles activities during mechanical ventilation in patients with ARDS. In present study, oleic acid-induced beagle dogs' ARDS models were employed and ventilated with the same level of mean airway pressure. Respiratory mechanics, lung volume, gas exchange and inflammatory cytokines were measured during mechanical ventilation, and lung injury was determined histologically. As a result, for the comparable ventilator setting, preserved inspiratory muscles activity groups resulted in higher end-expiratory lung volume (EELV) and oxygenation index. In addition, less lung damage scores a

SUBMITTER: Zhang X 

PROVIDER: S-EPMC5322359 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature