Expression profiling and bioinformatic analyses suggest new target genes and pathways for human hair follicle related microRNAs.

ABSTRACT:

Background

Human hair follicle (HF) cycling is characterised by the tight orchestration and regulation of signalling cascades. Research shows that micro(mi)RNAs are potent regulators of these pathways. However, knowledge of the expression of miRNAs and their target genes and pathways in the human HF is limited. The objective of this study was to improve understanding of the role of miRNAs and their regulatory interactions in the human HF.

Methods

Expression levels of ten candidate miRNAs with reported functions in hair biology were assessed in HFs from 25 healthy male donors. MiRNA expression levels were correlated with mRNA-expression levels from the same samples. Identified target genes were tested for enrichment in biological pathways and accumulation in protein-protein i

SUBMITTER: Hochfeld LM 

PROVIDER: S-EPMC5322611 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature