Genetic variation of the Toll-like receptors in a Swedish allergic rhinitis case population.

ABSTRACT:

Background

Variation in the 10 toll-like receptor (TLR) genes has been significantly associated with allergic rhinitis (AR) in several candidate gene studies and three large genome-wide association studies. These have all investigated common variants, but no investigations for rare variants (MAF ≤ 1%) have been made in AR. The present study aims to describe the genetic variation of the promoter and coding sequences of the 10 TLR genes in 288 AR patients.

Methods

Sanger sequencing and Ion Torrent next-generation sequencing was used to identify polymorphisms in a Swedish AR population and these were subsequently compared and evaluated using 1000Genomes and Exome Aggregation Consortium (ExAC) data.

Results

The overall level of genetic variation was clearly different amon

SUBMITTER: Henmyr V 

PROVIDER: S-EPMC5322632 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature