PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes.

ABSTRACT: The discovery of poly(ADP-ribose) >50 years ago opened a new field, leading the way for the discovery of the poly(ADP-ribose) polymerase (PARP) family of enzymes and the ADP-ribosylation reactions that they catalyze. Although the field was initially focused primarily on the biochemistry and molecular biology of PARP-1 in DNA damage detection and repair, the mechanistic and functional understanding of the role of PARPs in different biological processes has grown considerably of late. This has been accompanied by a shift of focus from enzymology to a search for substrates as well as the first attempts to determine the functional consequences of site-specific ADP-ribosylation on those substrates. Supporting these advances is a host of methodological approaches from chemical biology, proteomic

SUBMITTER: Gupte R 

PROVIDER: S-EPMC5322727 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature