Gene-specific DNA methylation may mediate atypical antipsychotic-induced insulin resistance.

ABSTRACT:

Objectives

Atypical antipsychotics (AAPs) carry a significant risk of cardiometabolic side effects, including insulin resistance. It is thought that the insulin resistance resulting from the use of AAPs may be associated with changes in DNA methylation. We aimed to identify and validate a candidate gene associated with AAP-induced insulin resistance by using a multi-step approach that included an epigenome-wide association study (EWAS) and validation with site-specific methylation and metabolomics data.

Methods

Subjects with bipolar disorder treated with AAPs or lithium monotherapy were recruited for a cross-sectional visit to analyze peripheral blood DNA methylation and insulin resistance. Epigenome-wide DNA methylation was analyzed in a discovery sample (n = 48) using the

SUBMITTER: Burghardt KJ 

PROVIDER: S-EPMC5322870 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature