Patterns of change in nesiritide use in patients with heart failure: how hospitals react to new information.

ABSTRACT:

Objectives

This study sought to determine hospital patterns of change in use of nesiritide over a 6-year period after publications of safety concerns in 2005 and to identify hospital characteristics associated with these patterns.

Background

The changing nature of medical evidence often requires a change in practice. Nesiritide was commercialized in 2001 for early relief of dyspnea in patients with decompensated heart failure. In 2005, concerns about its safety led to recommendations to restrict its use. Little is known about how hospitals responded to this information.

Methods

We analyzed data from the Premier database, including 403 hospitals contributing 813,783 hospitalizations with heart failure from 2005 to 2010. We applied a growth mixture modeling approach to

SUBMITTER: Partovian C 

PROVIDER: S-EPMC5322944 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature